Why Pall’s Allegro™ Stirred-Tank Bioreactor is ideal for viral vector cell culture

نویسندگان

چکیده

Viral vectors facilitate the delivery of genetic material to living cells for potential treatment multiple diseases. With recent regulatory approvals, rapid growth in demand viral vector-based products highlights need proven, scalable manufacturing solutions that can fully meet this and ultimately increase availability treatments. Pall’s AllegroTM STR stirred-tank bioreactor addresses scalability, as it be scaled up 2000 L enable manufacture vectors. In article, we discuss key attributes Allegro such design, agitation sparging which make ideal vector at a larger scale. Also, show process scalability under controlled parameters from 50 500 based on cell growth, metabolic profile, production.

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ژورنال

عنوان ژورنال: Cell & gene therapy insights

سال: 2022

ISSN: ['2059-7800', '2397-0545']

DOI: https://doi.org/10.18609/cgti.2022.118